We discuss a group of supplements known as Nootropics, and find out the dangerous truth about taking smart pills.
You may remember back in college when students took common prescription drugs like Ritalin or Adderall to help focus or finish up a research paper the night before it’s due. This was and still is a major problem, because students are using prescription meds that are not even subscribed to them, and are using them to treat conditions that they don’t even have. These pills carry dangerous side effects because of their misuse and ended up putting more young people at harm.
While the Adderall fad is now considered passé, a new trend is sweeping college campuses, high tech companies and really anyone feeling the pressures from their highly demanding stressful jobs. They’re called nootropics, aka smart pills. In 2015, the nootropics industry has already racked in nearly one billion dollars and it’s not showing signs of slowing down anytime soon.
What Are Nootropics?
Literally translated from Greek: “towards the mind”, these compounds either directly or indirectly influence our brain function. Proponents of nootropics claim these compounds can increase our capabilities, state of wellbeing and/or our learning potential, which is pretty significant. These compounds are able to do this by altering our neurochemicals, enzymes or hormones in our brain and increasing catecholamine signalling. Catecholamines include neurotransmitters such as dopamine and norepinephrine which control a variety of our brain’s functions like motor control, cognition, emotion and memory processing. For a compound to be considered a nootropic, it must improve at least one cognitive domain: attention, arousal, mood, memory and creativity.
Here’s a Nootropics history lesson, guys. A short one, I promise.
Corneliu E. Giurgea, a Romanian psychologist and chemist, was named the father of nootropics. In the 1960s, Giurgea and his colleagues were attempting to develop new sleeping pills, when they accidently discovered a common nootropic known as Piracetam. Instead of quieting the brain, Piracetam activated the brain which he soon labeled as a nootropic. Giurgea was famously quoted saying: “Man will not wait passively for millions of years before a solution offers him a better brain”. Instead of focusing solely on treatment, nootropics started to become used to enhance our brain health and are heavily encouraged among healthy individuals.
Since the discovery, the market for nootropics have exploded. In the UK, a new recent study found that a large population of healthy students are using nootropics to help them complete tasks that they commonly procrastinate with. According to this nootropics website, nootropics can benefit these areas:
- Useful for their productivity and motivational effects
- Boost in social ability (increase confidence, extroversion, and verbal fluidity)
- Improve exercise performance
- Support brain health
- Improvement of mental wellbeing (anxiety aid, mood brighteners, anti-depressants)
But the real question remains, do nootropics work? Let’s review a few common nootropics.
Piracetam is one of the most popular nootropics since it was first discovered by the father of nootropics, Giurgea. The downside with a lot of the studies looking at piracetam is that they are not conducted on individuals using nootropics, like young healthy individuals. Instead the majority of the studies are conducted on the elderly that have a variety of cognitive disorders. This makes it difficult to know whether piracetam can actually enhance or improve cognitive thinking in healthy individuals (basically the people currently using these pills).
Here are a few studies on piracetam:
In this study, brain function in elderly patients was improved after regular dosing with piracetam.
In this 1976 study, piracetam improved the memory in most adult volunteers after two weeks.
In this 1987 study, piracetam helped dyslexic students improve their nonverbal learning skills (reading ability/comprehension).
The trouble with a few of these old studies is that they haven’t been replicated since, have small sample sizes and were fairly short term, so it’s still unclear the impact piracetam has in long term use.
In 2001, a review was unable to find enough evidence to support the use of piracetam in the treatment of people with dementia or cognitive impairment.
On top of that, Cochran (an independent network that reviews health research reviewed hundreds of studies looking at the role of piracetam with dementia and Alzheimer’s found that there is insufficient evidence to confirm that it enhances thinking/memory.
Amongst all nootropics, modafinil is touted as the best. To use this nootropic, you must have a prescription. Modafinil is supposed to be used to treat ADHD, narcolepsy and other sleep disorders (obstructive sleep apnea). Modafinil acts by increasing dopamine levels (so does cocaine) which controls our brain’s reward and pleasure centers. In one study, modafinil helped “sleep-deprived surgeons become better at planning, redirecting their attention and being less impulsive when making decisions”. In another study, researchers concluded that it was difficult to extrapolate from disease to healthy state. Modafinil was able to help individuals with ADHD by slowing things down, however in healthy individuals, this nootropic may shift away from our optimal state, and slow things down as well. On top of that, modafinil is also associated with addictive tendencies, since it affects our dopamine levels and may lead to dangerous side effects, especially if individuals are using prescriptions that were not even prescribed to them in the first place.
So far, the research is telling us that in a disease state, nootropics can provide slight improvements, while in a healthy state, research is lacking in whether it can improve any cognitive abilities or that it provides us any additional benefits. We also don’t know whether prolonged use of these substances alter our brain chemistry and put us at harm over time.
The Dangers of Nootropics
Based on the research, there is a consensus that nootropics don’t provide any additional benefit in healthy individuals. One major concern with these substances is that in Canada, nootropics are not allowed to be sold for consumption because they have not yet been tested for safety by Health Canada, mainly because of the limited evidence. In the United States, they are seen as food products, so do not need to be approved to sell (that’s a whole other kind of blog post). The way Canadians get around this is by ordering nootropics online from American retailers. The concern with purchasing supplements online is that you don’t really know what your purchasing and they may be mixed with other substances or contaminated with dangerous compounds. A huge study by a Guelph researcher, Steve Newmaster found that one in three vitamins and supplements sold were fake. On top of that, 60% of vitamin and supplement products contained ingredients not listed on their labels. WHAT?! Keep in mind these are products that are supposed to be regulated by Health Canada, so imagine products that are not even regulated or deemed safe by our government? Scary thought.
There has also already been cases about the misuse of nootropics. In the United States, since they’re classified as dietary supplements, nootropics unregulated, so companies are not held accountable for providing adequate labels with clear instructions. Because of this, overdose cases have already been reported (check that out here.) In both of the overdose cases, they were young men stressed and overwhelmed with work and needed a pick me up so turned to these supplements. I have major beef with the FDA around this, because supplements are NOT the same as food and just because something is “natural” doesn’t mean it’s safe.
Think about this for a second.
1 teaspoons of caffeine powder can be equivalent to 16-25 cups of coffee. I’m pretty positive that’s not an average coffee run order.
When it comes to supplements, we can’t ignore the placebo effect because it’s especially plausible in this case. When nootropics are touted as mood boosters or social anxiety relievers, it’s highly likely you can easily trick yourself into believing they help you. And yes, they’ve done research on this. This study showed that prescription stimulants influenced an individual’s mood but not cognitive enhancement.
Natural Nootropics in Food
Enough about supplements, let’s talk about food. So maybe we don’t yet have enough research to support the use of nootropics, but we can find many of these compounds in food itself (and that’s a hell of a lot safer).
Eggs provide us with a rich source of choline which is the precursor to a neurotransmitter acetylcholine which is important for learning and memory. Our body can only produce small amounts of choline, so we must get it from food. You can also get choline from liver, seafood and shellfish.
I know you guys will like this one. For a while now, studies have found the link between dark chocolate consumption and cognitive function because of some antioxidant compounds known as flavanols. Regular intake of chocolate was significantly associated with stronger cognitive function “irrespective of other dietary habits”. Yaaaaaaaaaaas!
Green tea is notorious for carrying health benefits because of its antioxidant catechin and L-Theanine content. L-Theanine is a common nootropic and has been shown to promote relaxation which is why tea is often used as a calming device. Meanwhile, the catechins are known as flavanols, and like with chocolate, may promote brain function. In a small study, the consumption of green tea increased the connections between brain regions to aid in memory exercises.
Blueberries are high in flavonoids and have been shown to reduce rates of cognitive decline in older adults.
We’ve been talking about omega-3s and 6s for a while now, and it’s been heavily studied in the area of cognitive health. This 2017 review linked the consumption of omega-3 and omega-6 with healthy brain aging.
As you can see, you can benefit from some of these brain foods without having to spend a ton on supplements that may not even benefit you. There has even been a trend in the nutrition world toward brain diets.
The MIND Diet
The Mediterranean-DASH Intervention for Neurodegenerative Delay
is exactly what it looks like. A mash up of the Mediterranean diet and the DASH diet, both of which have been found to carry significant health benefits. This diet is not seen as another fad diet, but really a diet developed by public health experts and based on research. The DASH diet focuses on helping people eat foods that can lower their sodium intake and blood pressure, while the Mediterranean diet focuses on eating minimally processed natural foods and limiting unhealthy fats and red meat.
The diet recommends eating these ten foods daily:
- Green leafy vegetables
- Whole grains
- Olive oil
conducted on the MIND diet, results showed that the diet lowered the risk of Alzheimer’s by as much as 53% in participants that adhered to the diet.
For the time being, I am a food first kind of dietitian. There may be a role for nootropics in various neurological diseases and/or injury, however there is simply not enough evidence to suggest these pills will make the healthy lay person smarter. Save your money, don’t risk taking sketchy unregulated supplements, and eat real food.
What have you heard about these smart pills?
Have you or would you take them?
Have they worked for you?
Comment below with your thoughts!
Contribution by Sofia Tsalamlal, MHSc, RD
Updated on August 15th, 2020
Abbey Sharp is a Registered Dietitian (RD), regulated by the Ontario College of Dietitians. She is a mom, YouTuber, Blogger, award winning cookbook author, media coach specializing in food and nutrition influencers, and a frequent contributor to national publications like Healthline and on national broadcast TV shows.
I’m pretty devastated people read your misinformed lies. Most nootropics are actually quite safe, if they were dangerous then FDA would be all over it. The nootropics that were dangerous had been taken at doses over 50 times the recommended dose, they were tianeptine (in approved antidepressant abroad and in development in America for PTSD with an efficacy rating of over 70% in clinicals which is nearly 2.5 times more effective than traditional antidepressants)and phenibut. Phenibut (f-phenibut is an analogue that is has lower abuse and addiction potential due to increase specifity in the brain) is a gaba-b agonist at high doses it loses specifity and binds to gaba a receptors to induce stereotypes similar to being drunk. Your right about supplements/vitamins showing adulteration and lack of ingredients but legitimate nootropicvendors provide full lab tests and third-party testing proving authenticity. Also Omega 3s are yes beneficial but in healthy subjects show small improvement just like the aforementioned “nootropics”. You really shouldn’t make health claims about foods or any nootropics that you obviously lack the knowledge and education to comprehend. The fact you think modafinil is dangerous because of dopamine is a sad misconception. Modafinil has weak NDRI ability, it primarily activates histamine and orexin/hypocretin receptors to illicit a more “wakeful state”. These receptors are not g couple proteins and do not develop tolerance which basically means modafinil is non addictive. Which has been shown over and over. The prodrug that turns into modafinil is adrafinil and it’s available as a legal supplement because it has such an amazing safety rating.
Quality Noots (Angelo) says
I totally agree with you on nootropics like modafinil and piracetam, because they are in nature dangerous, because both are medications and not natural nootropics.
This in my opinion not makes all nootropics bad, or people shouldn’t be scared to use them because there are natural nootropics that have been proven to be healthy and bring lots of benefits.
And these are found in your foods and fruits.
All in all I love the post, great job!
Hope to read more from you!
Regards x Angelo
Abbey Sharp says
Thanks for your comment!
Have done a lot of research on nootropics over the years since being diagnosed with Complex PTSD, anxiety and depression. I definitely think it is important to research what you are putting into your body, and some disorders are not as easily managed with diet and exercise. Diet and exercise is a huge and critical part of any healthy lifestyle, however prescription medication for a lot of these disorders come with a very long and scary list of side effects. The right kinds of nootropics, something natural like lions mane mushrooms, have proven to be so helpful to rebuilding my cognitive state. Lions mane has been used for years in Chinese Medicine and Ancient Egypt to heal physical and mental trauma. I feel it unfair to dismiss nootropics as the same category as adderall. I take a daily nootropic that I did plenty of research on before choosing. I cannot stress enough the importance of research, like I said above. Your body is a temple, and it is yours to be careful what you choose to heal it. We should understand people have different paths and different struggles. I would have been considered a “layman” by many doctors, but these have really helped me heal in no way that prescription medication had helped me in the past (in fact, those medications made so many things worse for me). Thank you for your research and time taken to write this article. I felt obliged to share my experience as well.
Abbey Sharp says
Thanks so much for sharing your experience with nootropics.
HI Abbey….have you check out Metron Nootropics at nootropicsai.com? I think they have something good going on.
Abbey Sharp says
I’ll check that out, thanks!
I’ve had a number of students/patients asking for Adderall but haven’t heard of most the nootropics yet (other than modafinil)! Thanks for this post!
I’m all for green tea, blueberries, and salmon! <3 I don't do much caffeine but when I do, it's usually in the form of tea!
Abbey Sharp says
Love that! Thanks love
Emily @Sinful Nutrition says
So glad you covered this topic! I didn’t know too much about it before it!
Abbey Sharp says
Jessica Kuepfer says
I’ve never taken diet pills but this is absolutely terrifying. Thank you so much for taking the incredible amount of time to put out this post.
Also – if dark chocolate is healthy, sign me freaking UP!
Abbey Sharp says
Of course! Thanks love